10,008 research outputs found

    Correlated versus Ferromagnetic State in Repulsively Interacting Two-Component Fermi Gases

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    Whether a spin-1/2 Fermi gas will become ferromagnetic as the strength of repulsive interaction increases is a long-standing controversial issue. Recently this problem is studied experimentally by Jo et al, Science, 325, 1521 (2009) in which the authors claim a ferromagnetic transition is observed. This work is to point out the results of this experiment can not distinguish whether the system is in a ferromagnetic state or in a non-magnetic but strongly short-range correlated state. A conclusive experimental demonstration of ferromagnetism relies on the observation of ferromagnetic domains.Comment: 4 pages, 2 figures, published versio

    Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis

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    Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear deformation (nuclear protuberances), MPO synthesis, biomolecule oxidation and cell death. “Freezing” LPS-triggered macrophage activation with the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) prevented cell activation and death. Oxidation of proteins and genomic DNA was also blocked, with formation of protein- and DNA-DMPO nitrone adducts, as analyzed by immuno-spin trapping with a polyclonal anti-DMPO serum. Interestingly, confocal microscopy analysis of these cells showed that MPO, genomic DNA, and DNA-DMPO nitrone adducts co-localized in the nuclear protuberances. These observations, and the fact that DNA is negatively charged and MPO is a cationic protein, suggest a role for uptaken or newly synthesized MPO in oxidative genotoxicity induced by myeloid cells in sites of inflammation. 
In order to understand MPO-induced formation of DNA-centered radicals, we studied DNA-DMPO nitrone adducts in calf thymus DNA treated with micromolar concentrations of hypochlorous acid (HOCl) added as a bolus or generated in situ by the MPO/H2O2/Cl- system in the presence of DMPO. We also investigated DNA-DMPO nitrone adducts inside living cells containing MPO. The cell models we used were: i) human leukemia (HL)-60 cells, which overexpress MPO, ii) RAW 264.7 macrophages activated with LPS (1 ng/ml for 24 h), to induce MPO, and iii) A549 human airway epithelial cells pre-loaded with human MPO. When these cells were activated with the phorbol ester PMA, the number of 6-thioguanine-resistant cells with the hypoxanthine-guanine phosphoribosyl transferase (HRPT) mutation increased. This mutation was prevented by each of the following: the NADPH oxidase inhibitor apocynin; the MPO inhibitors salicylhydroxamic acid and 4-aminobenzoic acid hydrazide; the cell-permeable HOCl scavenger resveratrol; and DMPO, which traps DNA-centered radicals and prevents further oxidation. 
Genomic DNA-centered radicals and further mutagenesis induced by activated myeloid cells in sites of inflammation can be prevented by blocking MPO activity, preventing formation of and/or scavenging HOCl, or trapping DNA-centered radicals. Our findings provide new therapeutic avenues for preventing carcinogenesis induced by infiltration and activation of myeloid cells in sites of inflammation, for example, in the lung exposed to particulate matter. SUPPORTED BY NIEHS 5R00ES015415-03
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    The Three-Loop Free Energy for High-Temperature QED and QCD with Fermions

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    We compute the free energy density for gauge theories, with fermions, at high temperature and zero chemical potential. Specifically, we analytically compute the free energy through O(g4)O(g^4), which requires the evaluation of three-loop diagrams. This computation extends our previous result for pure gauge QCD.Comment: 26 pages, 9 postscript figures, UW/PT-94-1

    Precision microwave dielectric and magnetic susceptibility measurements of correlated electronic materials using superconducting cavities

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    We analyze microwave cavity perturbation methods, and show that the technique is an excellent, precision method to study the dynamic magnetic and dielectric response in the GHzGHz frequency range. Using superconducting cavities, we obtain exceptionally high precision and sensitivity for measurements of relative changes. A dynamic electromagnetic susceptibility ζ~(T)=ζ′+iζ′′\tilde{\zeta}(T)=\zeta ^{\prime}+i\zeta ^{\prime \prime} is introduced, which is obtained from the measured parameters: the shift of cavity resonant frequency δf\delta f and quality factor QQ. We focus on the case of a spherical sample placed at the center of a cylindrical cavity resonant in the TE011TE_{011} mode. Depending on the sample characteristics, the magnetic permeability μ~\tilde{\mu}, the dielectric permittivity ϵ~\tilde{\epsilon} and the complex conductivity σ~\tilde{\sigma} can be extracted from ζ~H\tilde{\zeta}_{H}. A full spherical wave analysis of the cavity perturbation is given. This analysis has led to the observation of new phenomena in novel low dimensional materials.Comment: 16 pages, 5 figure

    Expanded microchannel heat exchanger: design, fabrication and preliminary experimental test

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    This paper first reviews non-traditional heat exchanger geometry, laser welding, practical issues with microchannel heat exchangers, and high effectiveness heat exchangers. Existing microchannel heat exchangers have low material costs, but high manufacturing costs. This paper presents a new expanded microchannel heat exchanger design and accompanying continuous manufacturing technique for potential low-cost production. Polymer heat exchangers have the potential for high effectiveness. The paper discusses one possible joining method - a new type of laser welding named "forward conduction welding," used to fabricate the prototype. The expanded heat exchanger has the potential to have counter-flow, cross-flow, or parallel-flow configurations, be used for all types of fluids, and be made of polymers, metals, or polymer-ceramic precursors. The cost and ineffectiveness reduction may be an order of magnitude or more, saving a large fraction of primary energy. The measured effectiveness of the prototype with 28 micron thick black low density polyethylene walls and counterflow, water-to-water heat transfer in 2 mm channels was 72%, but multiple low-cost stages could realize the potential of higher effectiveness

    Antiferromagnetically Driven Electronic Correlation in Iron Pnictides and Cuprates

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    The iron pnictides and the cuprates represent two families of materials, where strong antiferromagnetic correlation drives three other distinct ordering tendencies: (1) superconducting pairing, (2) Fermi surface distortion, and (3) orbital current order. We propose that (1)-(3) and the antiferromagnetic correlation are the hallmarks of a class of strongly correlated materials to which the cuprates and pnictides belong. In this paper we present the results of the functional renormalization group studies to support the above claim. In addition, we show that as a function of the interlayer hopping parameter, the double layer Hubbard model nicely interpolates between the cuprate and the iron pnictide physics. Finally, as a check, we will present the renormalization group study of a ladder version of the iron pnictide, and compare the results to those of the two-dimensional model.Comment: 18 pages, 20 figures, revised version, one more figure added and references update
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